Targeted Protein Degradation

ABOUT ENDOTARGET

Endotarget is a biotechnology company developing a Targeted Protein Degradation platform.

Diseases such as cancer, inflammation, and neurodegeneration are rooted in the disruption of protein homeostasis and function. Small molecule drugs, the standard of care for most pathological conditions, work to modulate the function of disease-causing proteins by inhibiting the protein’s enzymatic activities. This therapeutic modality requires high affinity binding and sustained drug exposure for efficacy, limiting to targets with active binding site, and often insufficiently blocking the protein function. Targeted protein degradation instead aims to destroy disease-causing proteins through substoichiometric catalysis using the innate cellular machinery.

Endotarget is developing novel small molecule therapeutics that harness the body’s own natural protein disposal system (the ubiquitin proteasome system) to selectively and efficiently degrade and remove disease-causing proteins. We focus on high impact targets, identifying clinically validated biological pathways with key nodes or proteins that drive the pathogenesis of multiple serious diseases with limited or no known treatment options.